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Drug companies frequently seek approval to move popular drugs to over-the-counter sales in an effort to hang onto sales when a best-selling product loses its patent protection. Sales of erectile dysfunction drugs have soared since Viagra was approved in 1998, but the companies that sell them have also struggled against the social stigma of male impotence. It was approved by the FDA for sale in the United States in 2003. Unlike other erectile dysfunction drugs currently on the market, Cialis comes in two versions. One of the emergency situations is that when men start to suffer from erectile dysfunction blues, they need immediate treatment but inexpensive at that. As with many medications, the effectiveness of Cialis differs between men. Although more than 45 million men have taken Cialis, according to Lilly, the drug is not without risks: Like similar treatments, it should not be taken with some heart medications because it could cause an unsafe drop in blood pressure. 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